Chapter 3 Learning Outcomes

Learning Outcomes are summarized lists of the main ideas/skills that students should take away from a chapter. “Learning Outcomes” lists are not exhaustive; there may be other ideas/skills covered in the chapter that are also useful but not necessarily the main focus.

For Chapter 3 the Learning Outcomes are:

1. Understand the fundamentals of amines and ammonium cations.
2. Understand and be able to rank relative basicity for different amines.
3. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for syntheses of primary amines using phthalimide.
4. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for syntheses of primary amines using azide.
5. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for syntheses of primary amines using cyanide.
6. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for syntheses of primary/secondary/tertiary amines using reduction of iminium (reductive amination).
7. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for syntheses of primary/secondary/tertiary amines using reduction of amides.
8. Understand the fundamentals of heterocycles. Be able to name/recognize common heterocycles.
9. Understand the fundamentals of aromatic heterocycles.
10. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for acid-catalyzed syntheses of 5-membered aromatic heterocycles.
11. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for acid-catalyzed syntheses of 6-membered aromatic heterocycles using oxidation via a leaving group added after cyclization.
12. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for acid-catalyzed syntheses of 6-membered aromatic heterocycles using oxidation via a leaving group added during cyclization.
13. Predict the major product(s), required reagents/conditions, and draw the proposed mechanisms for acid-catalyzed syntheses of 6-membered aromatic heterocycles using oxidation via hydride acceptor.
14. Understand the fundamentals of nicotinamide adenine dinucleotide as a cofactor for hydride donor/acceptor reactions.